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KMID : 0369319940140020204
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Allergy
1994 Volume.14 No. 2 p.204 ~ p.214
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Specific Antibodies to Chironomus Plumosus(CP) and Tokunagayusurika Akamusi(TA) in Asthmatic patients Sensitized to CP or TA
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Abstract
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Chironomidae(non-biting midge) is recently considered as one of the most common inhalant allergens in many countries. To evaluate the role of specific antibodies to the development of asthmatic symptoms in chironomid-sensitive asthmatic patients,
we
performed bronchoprovocation test (BPT) with CP or TA extracts and detected specific antibodies (IgE, IgG and IgG4) to CP and TA by ELISA method in 29 CP and/or TA-sensitive asthmatic patients. Eight of them showed positive responses in CP-BPT(4
early
responders, 3late only responders, 1 dual responder). Seven of them showed positive responses in TA-BPT (5 early responders, 1 late only responder, 1 dual responder). Eight of them (53%) showed concurrent positive responses to other inhalant
allergens,
of which Dermatophagoides farinae was the most prevalent. Seven of them (47%) showed all negative responses on skin prick test except two chironomidas. CP-specific IgE antibody was detected in seven(88%) of eight positive responders on CP-BPT and
that
of TA was detected in six (86%) of seven positive responders on TA-BPT. There was no significant difference in specific IgC4 and IgG1 antibodies among positive and negative responders on BPT. There was one positive responder on TA-BPT who showed
high
specific IgG1 without specific IgE or IgG4 antibody. These results suggest that CP and TA can induce IgE-mediate bronchoconstrictions in sensitized patients and they sould be considered as those of the important inhalant allergens in asthmatic
patients
in this country.
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KEYWORD
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